Siddique started his career as a mimicry artist. He made his acting debut in 1985 for the film Aa Neram Alppa Dooram ( ആ നേരം അല്പദൂരം). During the last 35 years, he has acted in over 350 films. He started his career doing comedy roles during the 1990s and since 1997 has transitioned into more serious roles. He is also a film producer.